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KMID : 1059519900340030288
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Journal of the Korean Chemical Society
1990 Volume.34 No. 3 p.288 ~ p.296
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Synthesis of Cyclic Peticdes Related to GBⅠ-Ⅱand Study of Their Inhibitory Activity for Proteinases
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Kang Shin-Won
Huh Nam-Won
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Abstract
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Antielastic fragment in GBⅠ-Ⅱ differ on P1 site with that of antitryptic fragment in LBI. To obtain further understanding of the role of amino acid residue near the reactive site, specificity of P1 site and loop size, Tyr substituted cyclic nonapeptide and cyclic pentapeptide were synthesized and the inhibition constants for some proteinases were calculated by Dixon method. Cyclic nonapeptide showed no inhibition for chymotrypsin but appeared low inhibitory activity for trypsin and elastase and that of cyclic pentapeptide possessed inhibitory activity for chymotrypsin.
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KEYWORD
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